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The National Counterproliferation Center (NCPC) is the primary organization within the U.S. Intelligence Community for combating the spread of weapons of mass destruction and their delivery systems.
NCPC works with the Intelligence Community to identify critical intelligence gaps in counterproliferation collection or analysis and then develops solutions to help close those gaps. NCPC also works to find and fund new technologies to help combat proliferation. Additionally, NCPC works to identify “over the horizon” proliferation concerns and creates strategies to ensure that the IC is well-positioned to address them.
In 2004, then-Senate Majority Leader Bill Frist proposed a National Counterproliferation Center, noting that, "The greatest threat facing our country today is not solely a terrorist, but a terrorist armed with a weapon of mass destruction." 
He noted that a Center was needed "to focus, clarify and coordinate" U.S. efforts to stop the spread of chemical, biological and nuclear arms and missiles. Frist continued: "The bottom line is this: Just as we must take the offensive in the global war on terrorism, we must similarly take the offensive in stopping the proliferation of weapons of mass destruction. We need a good offense, and counterproliferation is just the answer.
At its founding, then-Director of National Intelligence John Negroponte noted that, “… NCPC will enhance our country's ability to prevent terrorists or terrorist-related entities from acquiring" WMD.
NCPC Funding of Counterproliferation Technologies
Shortly after its 2005 founding, NCPC established a fund to foster the development of innovative, counterproliferation technologies. It has been estimated that the fund “is in the low tens of millions.” 
According to a former ODNI budget official, “[The fund will] be seed money” that NCPC can focus toward worthwhile, cutting edge counterproliferation projects across the Intelligence Community.
Counterproliferation Reserve Corps
In a 2008 speech by Principal Deputy Director of National Intelligence Donald M. Kerr, “Our National Counterproliferation Center is trying to lead the way in developing a plan to have a Counterproliferation Reserve Corps. It's really an adjunct to the Intelligence Reserve Corps that we already have, but we're really trying to bring these people back in a way that we can get another ten years or so out of their accumulated knowledge. It's going to be very important not just in the proliferation area. I think there are a number of others where we're going to have that same issue.” 
Advisory Committee on Bioterrorism
In 2006, it was announced that NCPC had formed a committee of medical experts to collaborate with the Intelligence Community on biological threats. According to NCPC Director Brill, “While such a pandemic would be largely dealt with by those U.S. government agencies concerned with domestic and international public health issues, the Intelligence Community would be looked to for actionable medical intelligence about the spread of pandemic diseases that would not be available publicly…” 
NCPC received praise for this effort in the Report of the Commission on the Prevention of WMD Proliferation and Terrorism, which noted that, “NCPC also reaches out to elements inside and outside the U.S. government to identify new methods or technologies that can enhance the intelligence community’s capability to detect and defeat future proliferation threats.” 
- Ambassador Joseph DeTrani (2010 – 2012)
- Maja M. Lehnus (2012 - present)
Principal Deputy Director
- Robert Walpole (2005–Present)
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- ↑ 1.0 1.1 PHILIP SHENON (December 20, 2004), Next Round Is Set in Push To Reorganize Intelligence, The New York Times, http://query.nytimes.com/gst/fullpage.html?res=9B00EFD81230F933A15751C1A9629C8B63&fta=y, retrieved 2007-10-12
- ↑ 2.0 2.1 Bill Gertz (October 22, 2004), Fighting proliferation, The New York Times, http://www.gertzfile.com/gertzfile/ring102204.html, retrieved 2007-10-12
- ↑ ODNI (December 21, 2005), ODNI Announces Establishment of National Counterproliferation Center (NCPC), ODNI, http://www.dni.gov/press_releases/20051221_release.htm, retrieved 2007-10-12
- ↑ 4.0 4.1 ODNI (December 21, 2005), ODNI Progress Report, ODNI, http://www.fas.org/irp/dni/prog072706.pdf, retrieved 2007-10-12
- ↑ Inside the Pentagon (January 19, 2006), DNI Counterproliferation Center to Establish New Innovation Fund, Inside the Pentagon, http://www.insidedefense.com/, retrieved 2007-10-12
- ↑ Donald M. Kerr (January 19, 2006), PDDNI Delivers INSA Remarks, ODNI, http://www.dni.gov/speeches/20080306_speech.pdf, retrieved 2007-10-12
- ↑ Congressional Quarterly (May 8, 2006), Bioterrorism Panel To Link Intelligence, Medical Communities, CQ HealthBeat, http://stage.ihealthbeat.org/Email-Article.aspx?contentID=95957, retrieved 2007-10-12
- ↑ Commission on the Prevention of WMD Proliferation and Terrorism (May 8, 2006), Commission on the Prevention of WMD Proliferation and Terrorism, CQ, http://www.preventwmd.gov/world_at_risk_government_organization_and_culture/, retrieved 2007-10-12